Water → HCID 178449071, compound

Participants

Reaction Steps

To a stirred solution of 160.6 ml sulfuryl chloride in 1000 ml chloroform in a round bottomed flask equipped with a dropping funnel, thermometer, and magnetic stirrer was added dropwise 139.4 ml triethylamine and 168.5 ml dibutylamine with cooling in an ice-water bath to maintain a temperature of 15°-20° C. After the addition was complete, the reaction mixture was stirred without cooling for an additional hour, then poured into a mixture of ice and water (2000 ml). The chloroform phase was separated and washed with 10% hydrochloric acid (1000 ml) followed by ice cold water. The solution was dried over anhydrous calcium chloride (4-20 mesh). Evaporation of the solvent gave 147.7 g N,N-dibutylsulfonamide as a colorless oil.

Provenance & Evidence