Ammonium Chloride → HCID 86749069, compound

Participants

Reaction Steps

To a stirred solution of cis-4-(1-mercapto-1-methylethyl)-2-mercaptomethyl-4-butanolide (compound No.9-3, 0.102 g) in methylene chloride (3 ml), triethylamine (0.20 ml) and acetyl chloride (0.10 ml) were added and stirred for 30 minutes under nitrogen atmosphere and ice-cooling. The mixture was poured into saturated aqueous ammonium chloride solution (30 ml) and extracted with ether. The organic layer was washed with saturated aqueous ammonium chloride solution and saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo. The oily residue was purified by silica gel column chromatography to give 0.133 g (93%) of the titled compound.

Provenance & Evidence