Ammonia → HCID 86749072, compound

Participants

Reaction Steps

A solution of cis-N-benzyl-4-[1-(4-methoxybenzylthio)-1-methylethyl]-2-(4-methoxybenzylthiomethyl)-4-butanelactam (compound No.14-1, 0.40 g) in THF (8 ml) was added in liquid ammonia (60 ml). To the solution sodium metal (0.12 g) was added in a small portion under nitrogen atmosphere. After an addition of ammonium chloride, ammonia was evaporated and a product was extracted with ethyl acetate. The organic layer was washed with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo. The separated crystals were filtered to give 70 mg (46%) of the titled compound.

Provenance & Evidence