Hydrochloric Acid → HCID 86749073, compound

Participants

Reaction Steps

To a solution of 4-(1-benzylthio-1-methylethyl)-2-benzylthiomethyl-N-ethoxycarbonylmethyl-4-butanelactam (compound No.14-3, 1.50 g) in methanol (20 ml), 2N--KOH (6.4 ml) was added and the mixture was stirred for 1.5 hours at room temperature. The mixture was acidified with dilute hydrochloric acid and concentrated in vacuo. A product was extracted with ethyl acetate. The organic layer was washed with water and saturated sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo to give 0.94 g (67%) of the titled compound.

Provenance & Evidence