Sodium Hydroxide → HCID 10735834, compound

HRID 2211023Notes

Reaction equation

HRID 2211023 reaction equation
Cl.Cl.Cl.[NH2:4][C:5]([NH2:26])=[N:6][C:7](=[O:25])[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]2)=[C:10]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:9]=1.[OH-].[Na+]>O>[NH2:26][C:5]([NH2:4])=[N:6][C:7](=[O:25])[C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:19][CH2:18][CH:17]([NH2:20])[CH2:16][CH2:15]2)=[C:10]([S:21]([CH3:24])(=[O:22])=[O:23])[CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19377800HCID 19377800, compound

Product 1

HCID 10735834HCID 10735834, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.9 g of N-diaminomethylene-3-methylsulphonyl-4-(4-aminopiperidino)benzamide trihydrochloride (m.p. 232°-240°) are dissolved in 50 ml of water, and this solution is adjusted to pH 12 using 1N NaOH and stirred. The precipitate which forms is filtered off with suction, washed with 5 ml of water and dried at 50°. N-Diaminomethylene-3-methylsulphonyl-4-(4-aminopiperidino)benzamide is obtained, m.p. 239°-241°.

Workup

  1. filtrationThe precipitate which forms is filtered off with suction
  2. washwashed with 5 ml of water
  3. customdried at 50°

Sources & evidence

ORD record
ord-1c4a4b60659944c28e72c6de915165ea
Source dataset
uspto-grants-1995_10
Patent number
US05461066

Reaction notes

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