HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanethiol → 1-(1-Methyl-4-pyrazolylmethyl)2-(nitromethylene)tetrahydropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanethiol | HCID 878 | — |
| Reactant | 1,1-Bis(methylthio)-2-nitroethylene | HCID 83623 | — |
| Reactant | N-(1-methyl-4-pyrazolylmethyl)trimethylenediamine | HCID 14207161 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(1-Methyl-4-pyrazolylmethyl)2-(nitromethylene)tetrahydropyrimidine | HCID 70249087 | 70.1% |
Reaction Steps
A mixture of 16.8 g of N-(1-methyl-4-pyrazolylmethyl)-trimethylenediamine, 16.5 g of 1-nitro-2,2-bis(methylthio)ethylene and 200 ml of ethanol was heated under reflux until the generation of methylmercaptan ceased. The mixture was cooled, and the precipitated crystals were collected by filtration. Washing with methanol gave 16.6 g of the desired 1-(1-methyl-4-pyrazolylmethyl)2-(nitromethylene)tetrahydropyrimidine as pale yellow crystals. mp. 186°-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05461167 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-8ed4e899cd9b4a6eb0a58d9c367755a4 |
| Source note | uspto-grants-1995_10 |