Sodium borohydride → N-(2-chloro-5-pyridylmethyl)2-aminoethanethiol

A solution composed of 6-chloronicotinaldehyde (14.2 g), 2-aminoethanethiol (7.7 g) and benzene (80 ml) was heated with stirring for 5 hours while removing water as an azeotrope. After the reaction, benzene was distilled off under reduced pressure, and further volatile materials were removed at 1 mmHg and 70° C. to give 2-(2-chloro-5-pyridyl)thiazolidine (18 g)as a residue. Ten grams of 2-(2-chloro-5-pyridyl)thiazolidine was dissolved in 100 ml of ethanol, and sodium borohydride was added. With stirring, the mixture was gradually heated and thereafter refluxed for 1 hour. Ethanol was distilled off under reduced pressure, and chloroform was added to the residue. Insoluble materials were separated by filtration and the chloroform layer was washed with water and dehydrated. Chloroform was distilled off under reduced pressure to give the desired N-(2-chloro-5-pyridylmethyl)2-aminoethanethiol (8.3 g). nD24 : 1.5917.

1. temperaturethe mixture was gradually heated
2. temperaturerefluxed for 1 hour
3. distillationEthanol was distilled off under reduced pressure, and chloroform
4. additionwas added to the residue
5. customInsoluble materials were separated by filtration
6. washthe chloroform layer was washed with water
7. distillationChloroform was distilled off under reduced pressure

ORD record

ord-eeb4c64a9a9e4e45b0011d736cd1d236

Source dataset

uspto-grants-1995_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05461167