反应详情

0.443 g of 2-(2-decylindan-5-yl)pyrimidine-5-ol, 0.343 g of phenylpropyl p-toluenesulfonate and 0.1 g of potassium hydroxide were dissolved in 2 ml of ethanol, followed by heat-refluxing for 4 hours. After the reaction, the reaction mixture was poured into water and subjected to extraction with toluene. The resultant organic layer was washed with water and dried with anhydrous sodium sulfate, followed by distilling-off of the solvent and purification by silica gel column chromatography to obtain 0.313 g of an objective product (Yield: 53.2%).

1. temperatureby heat-refluxing for 4 hours
2. customAfter the reaction
3. extractionsubjected to extraction with toluene
4. washThe resultant organic layer was washed with water
5. dry with materialdried with anhydrous sodium sulfate
6. distillationfollowed by distilling-off of the solvent and purification by silica gel column chromatography