Sulfuric Acid → HCID 19375379, compound

Participants

Reaction Steps

To a solution of 4-hydroxy-4-p-iodophenyl-3-methyl-2-cyclobuten-1-one ethylene acetal (80 mg, 0.23 mmol dissolved in THF:H2O (3:1, 8 ml) was added dropwise 1N H2SO4 (3 ml) at room temperature. The reaction mixture was stirred for 4 h. The mixture was then diluted with ether (10 ml), and the organic fraction was separated from the aqueous phase by repeated extractions with ether (2×5 ml). The ether layer was dried over Na2SO4 and concentrated in vacuo to give a pale yellow oil (62 mg, 87%). 1H NMR (CDCl3) δ7.80 (d, J=9 Hz, 2H), 7.15 (d, J=9 Hz, 2H), 6.40 (s, 1H), 3.10 (s, 1H), 2.20 (s,3H).

Provenance & Evidence