Hydrochloric Acid → HCID 10421448, compound

Participants

Reaction Steps

10.0 g of phthalic anhydride was dissolved in 200 ml of tetrahydrofuran, and 40 ml of cyclohexylmagnesium chloride (2.0M, ether solution) was added dropwise to the solution at -50° C. After stirring the solution at the same temperature for 1 hour, the reaction solution was poured into 0.5-N hydrochloric acid, and extracted with chloroform. After the organic layer was dried over magnesium sulfide, it was purified by silica gel chromatography (eluent: chloroform-methanol) to obtain 12.0 g of o-(cyclohexanoyl) benzoic acid.

Provenance & Evidence