Sodium Hydroxide → HCID 53915411, compound

Participants

Reaction Conditions

Reaction Steps

1.1 g of 1-chloro-4-cyclohexylphthalazine and 1.6 g of D-α-phenylethylamine were dissolved in N-methylpyrrolidone, and the solution was stirred at 140° C. for 6 hours. After cooling the solution, an aqueous 5% NaOH solution was added to the solution, and the resultant solution was extracted with chloroform. The organic layer was dried, concentrated, purified by silica gel chromatography (eluent: hexane, chloroform, ethyl acetate), and recrystallized from ether to obtain 1.05 g of (R)-1-(α-phenylethylamino)-4-cyclohexylphthalazine.

Provenance & Evidence