Methane → HCID 86749076, compound

Participants

Reaction Steps

The free base compound, 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione [prepared as described in Example G herein], (4.4 g, 0.0096 mole) is dissolved in MeOH (125 ml), treated with activated charcoal, and filtered. To this solution is added a solution of maleic acid (2.23 g, 0.0192 mole) in one portion. The resulting mixture is stirred at room temperature for approximately 2 hours and is then collected, and air-dried. This solid is recrystallized from absolute EtOH/H2O (activated charcoal), filtered then cooled. The solid is collected, washed with anhydrous ether, air-dried and dried at 70° C. to give 4.99 g (0.0072 mole) of 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione di-2-Z-butenedioic acid salt.

Provenance & Evidence