HCID 10316830, compound → HCID 131719166, compound

Participants

Reaction Steps

This compound was obtained analogous to the method described in EP-A-0190472 for 1-(benzo-[b]furan-7-yl)-4-[3-(4-fluorobenzoyl)-propyl)piperazine using 1-(7-bromo-2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2-chloroethyl)piperazine (which was prepared similar to the method described for 1-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2-chloroethyl)piperazine as described in EP-A-0190472), and 6-chloro-3,4-dihydroisoquinolin-1(2H)-one. Yield 37%, m.p. <240° C. (dec.), 1H-NMR (DMSO:CDCI3 =4:1)δ3.09 (t, 2H, NCH2CH2Ar J=7 Hz), 3.16 (m, 2H, Hax pipCH2), 3.45 (m, 2H, +NCH2CH2), 3.55 (m, 2H, Heq pipCH2), 3.65-3.75 (cluster, 4H), 3.94 (t, 2H, CH2CH2NC=O), 4.26 (m, 4H, OCH2CH2O), 6.62 (d, 1 H, H-6, J=2 Hz), 6.75 (d, 1H, H-8 J=2 Hz), 7.37 (cluster, 2H), 7.88 (d, 1H, J=8 Hz), 11.0 (br, 1H, NH+)

Provenance & Evidence