N-(4-Bromobutyl)phthalimide → HCID 131719167, compound

HRID 2211143Notes

Reaction equation

HRID 2211143 reaction equation
[ClH:1].Cl.Br[C:4]1[CH:5]=[C:6]([N:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][CH2:23][N:24]3[C:28](=[O:29])[C:27]4[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=4S3(=O)=O)[CH2:16][CH2:15]2)[C:7]2[O:12][CH2:11][CH2:10][O:9][C:8]=2[CH:13]=1.BrCCCCN1C(=O)C2C(=CC=CC=2)[C:42]1=[O:51]>>[ClH:1].[Cl:1][C:4]1[CH:5]=[C:6]([N:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][CH2:23][N:24]3[C:42](=[O:51])[C:26]4[C:27](=[CH:30][CH:31]=[CH:32][CH:33]=4)[C:28]3=[O:29])[CH2:16][CH2:15]2)[C:7]2[O:12][CH2:11][CH2:10][O:9][C:8]=2[CH:13]=1

Participants

3

Reactant 2

HCID 93575N-(4-Bromobutyl)phthalimideHCID 131719168HCID 131719168, compound

Product 1

HCID 131719167HCID 131719167, compound

Procedure

This compound was prepared analogous to the method described for 2-(4-(4-(7-bromo-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)-butyl)-1H-isoindole-1,3(2H)-dione, dihydrochloride (Example 3) using intermediate 2a (1.30 g, 4.5 mmol) and 2-(4-bromobutyl)-1H-isoindole-1,3(2H)-dione (1.40 g, 4.9 mmol). Yield 2.20 g, m.p. 222°-4° C.

Workup

  1. customThis compound was prepared analogous to the method

Sources & evidence

ORD record
ord-b1caffe0ab9c4495b0bd143b8ff032d3
Source dataset
uspto-grants-1995_10
Patent number
US05462942

Reaction notes

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