HCID 19375631, compound → HCID 19375644, compound

HRID 2211145Notes

Reaction equation

HRID 2211145 reaction equation
O[C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]2)[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:11]=1.[Br:25]C1C=C(N2CCNCC2)C2OCCOC=2C=1>>[Br:25][C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][CH2:13]2)[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:11]=1

Participants

3

Reactant 2

HCID 19375631HCID 19375631, compoundHCID 19375648HCID 19375648, compound2×

Product 1

HCID 19375644HCID 19375644, compound

Procedure

The intermediate 1 -(7-bromo-2,3-dihydro-1,4-benzodioxin-5-yl)-4-(t-butyloxycarbonyl)piperazine was prepared similar to the method described for 1-(7-hydroxy-2,3-dihydro-1,4-benzodioxin-5-yl)-4-(t-butyloxycarbonyl)piperazine (Intermediate 12a) using 1-(7-bromo-2,3-dihydro-1,4-benzodioxin-5-yl)piperazine.

Sources & evidence

ORD record
ord-eb4ff6b8608d484a8e21ae740cf521cf
Source dataset
uspto-grants-1995_10
Patent number
US05462942

Reaction notes

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