Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methane | HCID 297 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 4-(4-Methoxyphenyl)-2-thiazolecarbonitrile | HCID 19375985 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 19375965 | HCID 19375965 | 66% |
Reaction Steps
A mixture of 4-(4-methoxyphenyl)-thiazole-2-carbonitrile (14.9 g) and pyridine hydrochloride (44.7 g) was heated at 225° C. for 1 h, then cooled and added to water (300 ml). The suspension was filtered and dried under vacuum at 50° C., to give a solid which was dissolved in methanol, treated with charcoal, filtered and recrystallised from methanol-water to give 4-(4-hydroxyphenyl)-thiazole-2-carbonitrile (9.2 g); m.p. 186°-197° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05462959 |
|---|
| Source dataset | uspto-grants-1995_10 |
|---|
| ORD ID | ord-551faabb9f9841acbde9820dbb63c3ce |
|---|
| Source note | uspto-grants-1995_10 |
|---|
