Lawesson's reagent → HCID 15039191, compound

Participants

Reaction Steps

Lawesson's Reagent (4.55 g, 11.26 mmoles) is added to a colorless solution of 2-[(3-trifluoromethylphenyl)amino]-benzamide (5.22 g, 18.64 mmoles) in 100 ml of tetrahydrofuran at room temperature. The resulting mixture is stirred under nitrogen for one hour, and then heated at reflux for 2.5 hours. The solution is concentrated in vacuo, and purified by flash chromatography with a gradient of 5:1 to 3:1 hexane/ethyl acetate as eluant, to provide 3.01 g (55%) of a bright yellow solid 2-[(3-trifluoromethylphenyl)amino]-benzene thioamide, mp 106°-108° C.

Provenance & Evidence