Cyanogen Bromide → HCID 14951345, compound

Participants

Reaction Steps

To a room temperature solution of 2-[(3-trifluoromethylphenyl)amino]benzoic acid hydrazide (532.7 mg, 1.81 mmoles) in 5 ml of dioxane is added sodium bicarbonate (155.0 mg, 1.84 mmoles) in 5 ml of water. After stirring at room temperature for five minutes, cyanogen bromide (192.0 mg, 1.81 mmoles) is added, and stirring is continued for 2.5 hours. The tan precipitate is removed by filtration and washed with 10 ml of 50% aqueous dioxane. Drying in vacuo provides 398.0 mg (69%) of 5-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]-1,3,4-oxadiazol-2-amine, mp 185°-187° C.

Provenance & Evidence