Methyl iodide → HCID 131719172, compound

HRID 2211200Notes

Reaction equation

HRID 2211200 reaction equation
[I:1][CH3:2].[C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:29])[NH:14][C:15]([C:17]2[CH:28]=[CH:27][C:20]([O:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])=[CH:19][CH:18]=2)=[O:16])=[CH:8][CH:7]=1)(=[S:5])[NH2:4]>CC(C)=O>[IH:1].[CH3:2][S:5][C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:29])[NH:14][C:15]([C:17]2[CH:28]=[CH:27][C:20]([O:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])=[CH:19][CH:18]=2)=[O:16])=[CH:8][CH:7]=1)=[NH:4]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 18986141HCID 18986141, compound

Product 1

HCID 131719172HCID 131719172, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Iodomethane (5 ml) was added to a stirred suspension of the product of step (b) (550 mg) in acetone (50 ml). The reaction mixture was stirred at ambient temperature for 2 days and then filtered. The collected solid was washed with acetone and dried to give methyl 4-[4-(4-methylthiocarbonimidoylphenyl)allophanoyl]phenoxyacetate, hydroiodide salt (550 mg), as a yellow solid; m.p. 216°-219° C. (decomposes); NMR Spectrum (DMSO-d6) 2.82 (3H, s), 3.71 (3H, s), 4.93 (2H, s), 7.09 (2H, d), 7.91 (4H, m), 8.05 (2H, d), 11.08 (1H, s), 11.28 (1H, s).

Workup

  1. filtrationfiltered
  2. washThe collected solid was washed with acetone
  3. customdried

Sources & evidence

ORD record
ord-4f9800333813450ca2bfbf58ebf02661
Source dataset
uspto-grants-1995_10
Patent number
US05463011

Reaction notes

Loading…