HCID 86749079, compound → HCID 15284548, compound

Participants

Reaction Steps

In 300 ml of methanol was dissolved 11.5 g of 3,3-dimethyl-4-hydroxyimino-1-[1-(R)-phenylethyl]-Pyrrolidin-2-one, and about 20 ml of Raney nickel washed with methanol was added to the solution. Reduction was conducted at room temperature for 16 hours in an egg-plant type flask. The catalyst was removed by filtration, and the solvent of filtrate was removed under reduced pressure. The residue was subjected to silica gel (400 g) column chromatography using a 30:1 (by volume) mixture of chloroform and methanol as an eluent to yield 3.75 g of Fraction 1 (lower polar material) and 10.2 g of a mixture of Fraction 1 and Fraction 2 (higher polar material).

Provenance & Evidence