Benzamidine → HCID 178516639, compound

HRID 2211214Notes

Reaction equation

HRID 2211214 reaction equation
[C:1]([NH2:9])(=[NH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10](OC)(=[O:16])[CH2:11][C:12](OC)=[O:13]>CS(C)=O>[C:2]1([C:1]2[N:9]=[C:12]([OH:13])[CH:11]=[C:10]([OH:16])[N:8]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 2332BenzamidineHCID 7943Dimethyl malonate

Product 1

HCID 178516639HCID 178516639, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of benzamidine (7.42 g) and dimethyl malonate (8.09 g) in dry dimethyl sulfoxide (7 mL) was allowed to stand at room temperature for 24 h. The precipitated product was collected and washed with water and ether to afford 2-Phenyl-4,6-dihydroxy-pyrimidine as a white solid.

Workup

  1. customThe precipitated product was collected
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-2551585d8b764420a9e1430ba08bc4d9
Source dataset
uspto-grants-1995_10
Patent number
US05463054

Reaction notes

Loading…