Bis(trifluoroacetoxy)iodobenzene → HCID 21803665, compound

HRID 2211281Notes

Reaction equation

HRID 2211281 reaction equation
N[C:2]([C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])=[CH:21][CH:20]=3)[N:16]([CH3:18])[CH:17]=2)=[CH:9][CH:8]=1)(C)[CH3:5])=O.FC(F)(F)C(OI(C1C=CC=CC=1)OC(=O)C(F)(F)F)=O.C(#[N:54])C.O>>[NH2:54][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([C:19]3[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])=[CH:21][CH:20]=3)[N:16]([CH3:18])[CH:17]=2)=[CH:9][CH:8]=1)([CH3:5])[CH3:2]

Participants

4

Reactant 3

HCID 102317Bis(trifluoroacetoxy)iodobenzeneHCID 18373917Acetonitrile--water (1/1)HCID 21803638HCID 21803638, compound

Product 1

HCID 21803665HCID 21803665, compound

Procedure

Prepared from 4-[4-(2-aminocarbonyl-2-propyl)-phenyl]-2-[4-(2-methoxycarbonyl-ethyl)-phenyl]-1-methyl-imidazole by treating with [bis(trifluoroacetoxy)iodo]benzene in acetonitrile/water at ambient temperature.

Sources & evidence

ORD record
ord-a5398ddd4f8349a588eb117a684511e5
Source dataset
uspto-grants-1995_10
Patent number
US05463071

Reaction notes

Loading…