HCID 178499321, compound → HCID 178435086, compound

HRID 2211290Notes

Reaction equation

HRID 2211290 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:28]([O:30]C)=[O:29])=[C:5]2[C:9]=1[N:8]=[CH:7][N:6]2[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]2[NH:27][N:26]=[N:25][N:24]=2)=[CH:13][CH:12]=1>[OH-].[Na+].CO>[CH3:1][C:2]1[S:3][C:4]([C:28]([OH:30])=[O:29])=[C:5]2[C:9]=1[N:8]=[CH:7][N:6]2[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[C:23]2[NH:24][N:25]=[N:26][N:27]=2)=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 178499321HCID 178499321, compound

Product 1

HCID 178435086HCID 178435086, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of methyl 4-methyl-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]thieno[3,4-d]imidazole-6-carboxylate (0.1 g) in a mixture of 1N NaOH (1.5 ml) and methanol (5 ml) was heated for two days under reflux. The reaction mixture was neutralized with 1N HC1 to give crystals. Recrystallization from methanol--ethyl acetate afforded colorless crystals (0.1 g, quantitatively), m p 187°-189° C. (dec.).

Workup

  1. temperaturewas heated for two days
  2. temperatureunder reflux
  3. customto give crystals
  4. customRecrystallization from methanol

Sources & evidence

ORD record
ord-a4806aaf052f42ad9a6c2f0f5ced9e82
Source dataset
uspto-grants-1995_10
Patent number
US05463073

Reaction notes

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