Trityl chloride → HCID 15291915, compound

Participants

Reaction Steps

Trityl chloride (0.6 g) was added to a solution of 2-ethylthio-4-methyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl ]methyl]thieno[3,4-d]imidazole-6-carboxylic acid (0.92 g) and triethylamine (0.3 ml) in dichloromethane (20 ml). The mixture was stirred for 30 minutes at room temperature. The reaction mixture was washed with water, dried, and then the solvent was evaporated ...in vacuo. The residue was purified by silica gel column chromatography to give crystals. Recrystallization from ethyl acetate - hexane afforded colorless needles (1.36 g, 98%), m.p. 138°-140° C.

Provenance & Evidence