Hydrochloric Acid → HCID 57105694, compound

Participants

Reaction Steps

19.5 g (0.13M) of the nitrile (XI) obtained in 1-9) above was dissolved in 200 ml of absolute ether under a nitrogen gas stream and 160 ml of a 1M solution of diisobutylaluminum hydride in hexane was added dropwise thereto at room temperature. Then the resulting mixture was stirred for one hour, poured into ice/water and acidified with 1N hydrochloric acid. The organic phase was collected and dried over anhydrous magnesium sulfate. After evaporation of the solvent, the residue was distilled under reduced pressure to give 19.0 g (theoretical yield: 96%) of the aimed compound (XII) as a colorless oily material. b.p.: 45° to 47° C./0.5 mmHg.

Provenance & Evidence