反应详情

A mixture of 1.1 g of 2-methyl-2-(1H-tetrazol-5-yl)-7-(2-ethyl-4-(4-fluorophenyl)-5-benzyloxyphenoxy)heptane, 1 g of 10% palladium on carbon, and 200 mL of ethanol was hydrogenated on a Parr™ apparatus at 35-40 psi for 2 hours. The mixture was filtered and the filtrate evaporated in vacuo. The residue was chromatographed on silica gel eluting with dichloromethane/methanol providing 750 mg (84%) of the desired title product. MS, NMR. Crystallization from diethyl ether/hexanes gave material with a melting point of 135°-137° C.; when crystallized from toluene, the melting point was 142°-143° C.

1. filtrationThe mixture was filtered
2. customthe filtrate evaporated in vacuo
3. customThe residue was chromatographed on silica gel eluting with dichloromethane/methanol providing 750 mg (84%) of the desired title product
4. customCrystallization from diethyl ether/hexanes
5. customgave material with a melting point of 135°-137° C.
6. customwhen crystallized from toluene