HCID 10160327, compound → HCID 10554772, compound

HRID 2211377Notes

Reaction equation

[CH2:1]([C:3]1[CH:34]=[C:33]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[C:32]([OH:42])=[CH:31][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21](N(C)C)=[O:22])[C:11]=1[CH2:26][CH2:27][C:28]([OH:30])=[O:29])[CH3:2].C(C1C=C(C2C=CC(F)=CC=2)C(O)=CC=1[O:47]CCCOC1C=CC=CC=1CCC(O)=O)C>>[CH2:1]([C:3]1[CH:34]=[C:33]([C:35]2[CH:40]=[CH:39][C:38]([F:41])=[CH:37][CH:36]=2)[C:32]([OH:42])=[CH:31][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:47])=[O:22])[C:11]=1[CH2:26][CH2:27][C:28]([OH:30])=[O:29])[CH3:2]

Participants

Reactant 2

HCID 10160327HCID 10160327, compound

HCID 10303707HCID 10303707, compound

Product 1

HCID 10554772HCID 10554772, compoundYield 42%

Procedure

3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-dimethylaminocarbonylbutyloxy)phenyl)propionic acid, 42% yield, NMR. ##STR21## 4. 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)phenyl)propionic acid, 15% yield, NMR, MS. ##STR22## 5. 3-(2-(3-(2-Ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-(4-carboxybutyloxy)phenyl)propionic acid, yield, NMR, MS.

Sources & evidence

ORD record: ord-bfb35143534d48afb76142016ff284b0
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05462954

Reaction notes

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