Ethyl 3-(2-hydroxyphenyl)propanoate → HCID 19375831, compound

HRID 2211387Notes

Reaction equation

HRID 2211387 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:18]([O:19][CH3:20])=[CH:17][C:11]([O:12][CH2:13][CH2:14][CH2:15]Cl)=[C:10]([Br:21])[CH:9]=2)=[CH:4][CH:3]=1.[OH:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[Br:21][C:10]1[CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[C:18]([O:19][CH3:20])=[CH:17][C:11]=1[O:12][CH2:13][CH2:14][CH2:15][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32]

Participants

3

Reactant 2

HCID 12263583Ethyl 3-(2-hydroxyphenyl)propanoateHCID 19375793HCID 19375793, compound

Product 1

HCID 19375831HCID 19375831, compoundYield 76%

Procedure

The title intermediate was prepared from 3-(4-(4-fluorophenyl)-2-bromo-5-methoxyphenoxy)propyl chloride and ethyl 3-(2-hydroxyphenyl)propionate in 76% yield by the procedure of Preparation 36. NMR

Sources & evidence

ORD record
ord-37b7930ab43849c3bc31de33ccff36a2
Source dataset
uspto-grants-1995_10
Patent number
US05462954

Reaction notes

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