Hydrochloric Acid → HCID 67736902, compound

Participants

Reaction Steps

A solution of 6.3N hydrochloric acid in 20 cm3 of dioxane is added to a solution of 2.07 g of (3aS,4S,7aS)-7,7-diphenyl-4-fluoro-4-(2-methoxyphenyl)-2-tert-butoxycarbonyl-perhydroisoindole in 20 cm3 of dioxane at room temperature. The reaction mixture is stirred at this temperature for 3 hours and then concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallised in 40 cm3 of absolute ethanol and the crystals are filtered off and then dried. 1 g of (3aS,4S,7aS)-7,7-diphenyl-4-fluoro-4-(2-methoxyphenyl)-perhydroisoindole hydrochloride is obtained in the form of white crystals which melt at 270° C.

Provenance & Evidence