反应详情

温度

65 °C

A mixture of 2 g of (3aRS,4RS,5RS,7aRS)-2-benzyl-7,7-diphenyl-4-(2-methoxyphenyl)-perhydroisoindole-4,5-diol and 50 cm3 of ethanol is heated at 65° C., while stirring; 0.65 g of 20% palladium hydroxide-on-charcoal is added and the reaction mixture is then hydrogenated at a temperature of 65° C. and under atmospheric pressure, while stirring. After a reaction time of 1 hour, the theoretical volume of hydrogen has been absorbed; the reaction mixture is filtered and then concentrated to dryness under reduced pressure (2.7 kPa). The residue is crystallised in 10 cm3 of isopropyl ether. 1.45 g of (3aRS,4RS,5RS,7aRS)-7,7-diphenyl-4-(2-methoxyphenyl)-perhydroisoindole-4,5-diol which melts at 230° C. are obtained.

1. customis then hydrogenated at a temperature of 65° C. and under atmospheric pressure
2. stirringwhile stirring
3. customAfter a reaction time of 1 hour, the theoretical volume of hydrogen has been absorbed
4. filtrationthe reaction mixture is filtered
5. concentrationconcentrated to dryness under reduced pressure (2.7 kPa)
6. customThe residue is crystallised in 10 cm3 of isopropyl ether