HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Methoxyphenyl)acetic acid → (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(3-methoxyphenyl)acetyl]perhydroisoindol-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Methoxyphenyl)acetic acid | HCID 15719 | — |
| Reactant | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride | HCID 70218598 | — |
| Product | (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(3-methoxyphenyl)acetyl]perhydroisoindol-4-ol | HCID 15289537 | 58.5% |
Reaction Steps
By working in accordance with Use Example 4, starting from 0.75 g of (3aS,4S,7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-perhydroisoindol-4-ol hydrochloride and 0.28 g of (3-methoxyphenyl)-acetic acid, 0.54 g of (3aS, 4S, 7aS)-7,7-diphenyl-4-(2-methoxyphenyl)-2-[(3-methoxyphenyl)-acetyl]-perhydroisoindol-4-ol is obtained in the form of white crystals which melt at 185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05463077 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-313da6dbbc454141bbb5a2444bace561 |
| Source note | uspto-grants-1995_10 |