Ammonia → 3-Chloroquinoxalin-2-amine

HRID 2211566Notes

Reaction equation

HRID 2211566 reaction equation
[Cl:1][C:2]1[C:11](Cl)=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH3:13]>>[NH2:13][C:11]1[C:2]([Cl:1])=[N:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[N:10]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 166592,3-Dichloroquinoxaline

Product 1

HCID 8172743-Chloroquinoxalin-2-amine

Procedure

2.1 g (10.4 mmol) of 2,3-dichloroquinoxaline are stirred for 8 hours with 50 ml of 20% ethanolic ammonia in an autoclave at 80°–85° C. and autogenous pressure. The reaction solution is evaporated to dryness in a rotary evaporator, and the crude product is chromatographed over silica gel using toluene/ethyl acetate. The product-containing fractions are collected and evaporated in a rotary evaporator. Yield: 1.18 g (63%)

Workup

  1. customThe reaction solution is evaporated to dryness in a rotary evaporator
  2. customthe crude product is chromatographed over silica gel
  3. customThe product-containing fractions are collected
  4. customevaporated in a rotary evaporator

Sources & evidence

ORD record
ord-e554a052c4ba4202a78802598237d28d
Source dataset
uspto-grants-2006_09
Patent number
US07101537B2

Reaction notes

Loading…