HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2211607Generated: October 29, 2026
Hydrochloric Acid → 3-(3-(Piperidin-1-yl)propyl)-5-(trifluoromethyl)benzenamine
https://huagongshe.com/reaction/2211607
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[3-(3-Piperidin-1-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide | HCID 21959446 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(3-(Piperidin-1-yl)propyl)-5-(trifluoromethyl)benzenamine | HCID 21959527 | — |
Reaction Steps
N-[3-(3-Piperidin-1-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide (1.33 g) was dissolved in EtOH (40 mL) and 12 N HCl (40 mL) was added. After stirring overnight at 70° C. and RT, the mixture was concentrated in vacuo, affording 3-(3-piperidin-1-yl-propyl)-5-trifluoromethyl-phenylamine as a brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07101868B2 |
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| Source dataset | uspto-grants-2006_09 |
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| ORD ID | ord-7876b978aee5414f98c95139a2cb3c3a |
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| Source note | uspto-grants-2006_09 |
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