Ammonia → 4-nitro-2,3-dihydro-1H-isoindol-1-one

Participants

Reaction Steps

NH3 (2.0 M in MeOH, 50 mL) was slowly added to the solution of 2-bromomethyl-3-nitro-benzoic acid methyl ester (4.46 g, contaminated with a small amount of assumed starting material, 16.3 mmol) in 30 mL of MeOH at RT. The resulting mixture was stirred at RT overnight, to provide the title compound as a white solid. MS (ES+): 179.2 (M+H)+. Calc'd for C8H6N2O3-178.14.

Provenance & Evidence