4-Fluorobenzylamine → HCID 58696822, compound

Participants

Reaction Conditions

Reaction Steps

2-Fluoro-N-[3-(1-methyl-pyrrolidin-2-ylmethoxy)-5-trifluoromethyl-phenyl]-nicotinamide (300 mg), TEA (314 μL) and 4-fluorobenzylamine (170 μL) were combined in a sealed tube and heated to 90° C. for 3 h. Cooled to RT and the mixture was diluted with EtOAc, washed with sat. NH4Cl (2×), brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (CH2Cl2/MeOH/NH4OH 95/5/0.5) to provide an off-white foam upon drying. M+H 503. Calc'd for C26H26F4N4O2: 502.20.

Provenance & Evidence