4-Fluorobenzylamine → HCID 10070305, compound

HRID 2211678Notes

Reaction equation

HRID 2211678 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:14]2[CH:19]=[C:18]([Cl:20])[N:17]=[N:16][C:15]=2ON2C3C=CC=CC=3N=N2)=[O:13])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:31][C:32]1[CH:39]=[CH:38][C:35]([CH2:36][NH2:37])=[CH:34][CH:33]=1>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]([C:14]2[CH:19]=[C:18]([Cl:20])[N:17]=[N:16][C:15]=2[NH:37][CH2:36][C:35]2[CH:38]=[CH:39][C:32]([F:31])=[CH:33][CH:34]=2)=[O:13])=[CH:9][CH:10]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 673264-FluorobenzylamineHCID 86588706HCID 86588706, compound

Product 1

HCID 10070305HCID 10070305, compound

Conditions

Temperature
60 °C

Procedure

A mixture of 3-(benzotriazol-1-yloxy)-6-chloro-pyridazine-4-carboxylic acid (4-tert-butyl-phenyl)-amide (0.348 g, 0.82 mmol) and 4-fluorobenzylamine (1.0 mL, 8.75 mmol) was stirred at 60° C. under N2 for 30 min, cooled to RT, and purified by flash column chromatography. The desired compound was obtained as a solid. MS (ES+) 413.0 (M+H)+. Calc'd for C22H22ClFN4O-412.89.

Workup

  1. temperaturecooled to RT
  2. custompurified by flash column chromatography

Sources & evidence

ORD record
ord-adced8a1477147d1918a4d55293f7514
Source dataset
uspto-grants-2006_09
Patent number
US07101868B2

Reaction notes

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