HCID 10070305, compound → HCID 10429738, compound

Participants

Reaction Steps

A mixture of 6-chloro-3-(4-fluoro-benzylamino)-pyridazine-4-carboxylic acid (4-tert-butyl-phenyl)-amide (0.210 g, 0.51 mmol) and Pd/C (50 mg, 10% weight) in 10 mL of MeOH was placed under H2 from a balloon and stirred at RT for 26 h, filtered through Celite®, condensed, and purified by flash column chromatography (0.5% to 2% of MeOH in CH2Cl2, then 1% of MeOH and 1% of NH4OH in CH2Cl2). The titled product was obtained as a light yellowish solid. MS (ES+): 379.0(M+H)+. Calc'd for C22H23FN4O-378.44.

Provenance & Evidence