4-Fluorobenzoyl chloride → 4-Fluoro-N-[3-(4-isopropylphenyl)-1',4,6,7-tetramethylspiro[benzofuran-2(3H),4'-piperidine]-5-yl]benzamide

Participants

Role	Name	HCID	Charge
Reactant	4-Fluorobenzoyl chloride	HCID 67879	—
Reactant	Diisopropylether methanol	HCID 21882575	—
Reactant	3-(4-Isopropylphenyl)-1',4,6,7-tetramethylspiro[benzofuran-2(3H),4'-piperidine]-5-amine	HCID 21961302	—
Product	4-Fluoro-N-[3-(4-isopropylphenyl)-1',4,6,7-tetramethylspiro[benzofuran-2(3H),4'-piperidine]-5-yl]benzamide	HCID 10185404	38%

Reaction Steps

By using 3-(4-isopropylphenyl)-1′,4,6,7-tetramethylspiro[benzofuran-2(3H),4′-piperidine]-5-amine and 4-fluorobenzoyl chloride, the title compound was synthesized according to Example 1b. Yield: 38%. Melting point: 271-272° C. (Methanol-isopropyl ether).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07101867B2
Source dataset	uspto-grants-2006_09
ORD ID	ord-55236327044e44f290630d611a5c3caa
Source note	uspto-grants-2006_09