1,3-Benzodioxole-5-carbonyl chloride → HCID 21961309, compound

HRID 2211802Notes

Reaction equation

HRID 2211802 reaction equation
[CH3:1][C:2]1([CH3:22])[CH:6]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[C:5]2[C:14]([CH3:21])=[C:15]([NH2:20])[C:16]([CH3:19])=[C:17]([CH3:18])[C:4]=2[O:3]1.[O:23]1[C:27]2[CH:28]=[CH:29][C:30]([C:32](Cl)=[O:33])=[CH:31][C:26]=2[O:25][CH2:24]1>C(OCC)(=O)C.CCCCCC>[CH3:1][C:2]1([CH3:22])[CH:6]([C:7]2[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][CH:12]=2)[C:5]2[C:14]([CH3:21])=[C:15]([NH:20][C:32]([C:30]3[CH:29]=[CH:28][C:27]4[O:23][CH2:24][O:25][C:26]=4[CH:31]=3)=[O:33])[C:16]([CH3:19])=[C:17]([CH3:18])[C:4]=2[O:3]1

Participants

4

Reactant 2

HCID 27347491,3-Benzodioxole-5-carbonyl chlorideHCID 106853092,2,4,6,7-Pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-amine

Product 1

HCID 21961309HCID 21961309, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By using 2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-amine and 1,3-benzodioxol-5-carbonyl chloride, the title compound was synthesized according to Example 1b. Yield: 65%. Melting point: 164-165° C. (Ethyl acetate-hexane).

Sources & evidence

ORD record
ord-d3d2e0d8a6af4944bdf7441ff40b3c9a
Source dataset
uspto-grants-2006_09
Patent number
US07101867B2

Reaction notes

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