Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Uracil | HCID 1174 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(Hydroxymethyl)uracil | HCID 78168 | 44% |
Reaction Steps
A mixture of uracil (3.6 g, 32.1 mmol), formaldehyde (37% in water) (3.25 ml), KOH (1.4 g, 25 mmol) in water (45 ml) was stirred at 50° C. for 20 h. The reaction was acidified with 1 N HCl to give a white precipitate. The solids were collected dried under vacuum to give the 5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione (2.01 g, 44%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07101883B2 |
|---|
| Source dataset | uspto-grants-2006_09 |
|---|
| ORD ID | ord-3abb09e205ff4e8abed8834728a6277f |
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| Source note | uspto-grants-2006_09 |
|---|
