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Thionyl Chloride → 5-(Chloromethyl)uracil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 5-(Hydroxymethyl)uracil | HCID 78168 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 5-(Chloromethyl)uracil | HCID 236125 | 100% |
反応手順
Thionyl chloride ((10 ml) was added to a suspension of 5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione (0.60 g, 4.2 mmol)from step (11a) in dioxane (15 ml). The reaction was heated to reflux for 4 h, allowed to cool, and concentrated in vacuo to give the 5-(chloromethyl)-2,4(1H,3H)-pyrimidinedione (0.62 g, 100%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07101883B2 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-7ba52a75ba89449ebaa88639d2057de4 |
| 出典メモ | uspto-grants-2006_09 |