Potassium Hydroxide → HCID 21963047, compound

Participants

Reaction Steps

A mixture of 4-chlorouracil (0.87 g, 6.0 mmol), 4-mercaptophenol(0.834 g, 6.6 mmol) and KOH (0.435 g, 6.6 mmol) in ethanol (36 ml) was heated to reflux for 24 h. The reaction was allowed to cool, was concentrated in vacuo, and acidified with 1 n HCl. The solids were collected, washed with water and dried to give 6-[(4-hydroxyphenyl)thio]-2,4(1H,3H)-pyrimidinedione (1.1 g, 80%) as a white solid.

Provenance & Evidence