(R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid → HCID 10318743, compound

HRID 2211846Notes

Reaction equation

HRID 2211846 reaction equation
C(OC([NH:8][C@H:9]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:10][C:11]([OH:13])=O)=O)(C)(C)C.[C:24]([N:28]1[CH2:34][CH2:33][CH2:32][NH:31][CH:30]([CH3:35])[C:29]1=[O:36])([CH3:27])([CH3:26])[CH3:25]>>[NH2:8][C@H:9]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:10][C:11]([N:31]1[CH2:32][CH2:33][CH2:34][N:28]([C:24]([CH3:26])([CH3:25])[CH3:27])[C:29](=[O:36])[C@H:30]1[CH3:35])=[O:13]

Participants

3

Reactant 2

HCID 7146288(R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acidHCID 21962095HCID 21962095, compound

Product 1

HCID 10318743HCID 10318743, compound

Procedure

The title compound was prepared from (3R)-3-[(tert-butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid and 1-tert-butyl-hexahydro-3-methyl-2H-1,4-diazepin-2-one by the method described in Example 3, Step C and D. LC/MS 400.1 (M+1).

Sources & evidence

ORD record
ord-5cbec68b713146caa9ab9676ed5ca3f7
Source dataset
uspto-grants-2006_09
Patent number
US07101871B2

Reaction notes

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