5-Fluoro-2-nitrophenylacetic acid → HCID 21963258, compound

HRID 2211868Notes

Reaction equation

HRID 2211868 reaction equation
Cl.[N:2]1([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[S:10][N:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[F:17][C:18]1[CH:19]=[CH:20][C:21]([N+:28]([O-:30])=[O:29])=[C:22]([CH2:24][C:25](O)=[O:26])[CH:23]=1>>[S:10]1[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:8]([N:2]2[CH2:7][CH2:6][N:5]([C:25](=[O:26])[CH2:24][C:22]3[CH:23]=[C:18]([F:17])[CH:19]=[CH:20][C:21]=3[N+:28]([O-:30])=[O:29])[CH2:4][CH2:3]2)=[N:9]1

Participants

3

Reactant 2

HCID 103978545-Fluoro-2-nitrophenylacetic acidHCID 115217113-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride

Product 1

HCID 21963258HCID 21963258, compoundYield 50%

Procedure

1-(4-1,2-Benzisothiazol-3-yl-piperazin-1-yl)-2-(5-fluoro-2-nitro-phenyl)-ethanone was prepared according to the general method as outlined in Preparation 12 starting from 3-piperazin-1-yl-benzoisothiazole hydrochloride (1.31 g, 5.1 mmol) and (5-fluoro-2-nitro-phenyl)-acetic acid (800 mg, 4.3 mmol). The product was isolated via column chromatography to afford 870 mg of an off white foam. Yield 50%; mp 72° C.; MS (APCI): 401 [M+H]+.

Workup

  1. customThe product was isolated via column chromatography
  2. customto afford 870 mg of an off white foam

Sources & evidence

ORD record
ord-2ae6ad40c1cc4b86acc0bf24f0f2161f
Source dataset
uspto-grants-2006_09
Patent number
US07101886B2

Reaction notes

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