3-Methyl-2-butenoyl chloride → HCID 86594325, compound

Participants

Reaction Steps

Starting from 2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4,5-dimethoxy phenylamine (300 mg, 0.75 mmol) and 3,3 dimethyl acryloyl chloride (87.7 μL, 0.79 mmol) and following the procedure as outlined in Example 1, 246 mg of 3-methyl-but-2-enoic acid {2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4,5-dimethoxy-phenyl}-amide was isolated as a white foam in 100% purity @ 254 nm; LCMS (APCI): 481 [M+H]+; mp 58° C.

Provenance & Evidence