Acetyl chloride → N-{2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenyl}-acetamide

Participants

Role	Name	HCID	Charge
Reactant	Acetyl chloride	HCID 6367	—
Reactant	2-[2-(4-1,2-Benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenylamine	HCID 21963218	—
Product	N-{2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenyl}-acetamide	HCID 21963316	25.7%

Reaction Steps

Starting from 2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenylamine (142 mg, 0.4 mmol) and acetyl chloride (32.7 μL, 0.4 mmol) and following the procedure as outlined in Example 1, 41 mg of N-{2-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-4-fluoro-phenyl}-acetamide was isolated as a yellow foam in 100% purity @ 254 nm; LCMS (APCI): 399 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07101886B2
Source dataset	uspto-grants-2006_09
ORD ID	ord-1eee0bf922904fd48580aa3ae4cafca2
Source note	uspto-grants-2006_09