反应详情

To a 2 dram vial was added 0.20 g (0.6 mmol) 4-[2-(4-1,2-benzisothiazol-3-yl-piperazin-1-yl)-ethyl]-phenylamine, 6.0 mL CH2Cl2, and 104 mg (0.6 mmol) N-bromosuccinimide. The reaction was stirred for 30 min at rt and then quenched with 1 M Na2SO3. The organic layer was separated, dried, and concentrated in vacuo. The deep red product was purified by MPLC to give 0.059 g (24% yield) of a clear, tacky liquid. MS (APCI): 419 [M+H]+.

1. customquenched with 1 M Na2SO3
2. customThe organic layer was separated
3. customdried
4. concentrationconcentrated in vacuo
5. customThe deep red product was purified by MPLC
6. customto give 0.059 g (24% yield) of a clear, tacky liquid