4-Fluorobenzenesulfonyl chloride → HCID 15713288, compound

HRID 22119Notes

Reaction equation

HRID 22119 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:6][CH:5]=1.[F:25][C:26]1[CH:31]=[CH:30][C:29]([S:32](Cl)(=[O:34])=[O:33])=[CH:28][CH:27]=1>>[F:25][C:26]1[CH:31]=[CH:30][C:29]([S:32]([NH:1][CH2:2][CH2:3][C:4]2[CH:5]=[CH:6][C:7]([CH:10]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:8][CH:9]=2)(=[O:34])=[O:33])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 15713283HCID 15713283, compound

Product 1

HCID 15713288HCID 15713288, compoundYield 66%

Procedure

Prepared analogously to Example 13 from 7-(4-(2-aminoethyl)phenyl)-7-(3-pyridyl)heptanoic acid and 4-fluorobenzenesulphonic acid chloride. Yield: 66% of theory, Resin, Rf value: 0.20 (silica gel: chloroform/methanol=10:1) C26H29FN2O4S (484.6) Calculated: C 64.44 H 6.03 N 5.72 Found: 64.48 5.99 5.72

Sources & evidence

ORD record
ord-325e2d7bf3224c0c9aeb673feb78712c
Source dataset
uspto-grants-1995_06
Patent number
US05426119

Reaction notes

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