Water → HCID 68960656, compound

Participants

Reaction Steps

3 g of 17β-cyano-3,3-dimethoxyestr-5(10)-ene are suspended in a mixture of 24 ml of dichloromethane and 70 ml of t-butanol. After addition of 28 ml of water and 0.11 ml of 60% perchloric acid, the batch is stirred until fully reacted, admixed with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic phase is washed with saturated aqueous sodium chloride solution, dried over sodium sulfate and filtered and the filtrate is evaporated to dryness to leave 17β-cyanoestr-5(10)-en-3-one which is further processed without purification.

Provenance & Evidence