反应详情

N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-N-methyl-acetamide was prepared according to the general method as outlined in Preparation 43 starting from N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-acetamide (0.450 g, 2.126 mmol) and iodomethane (0.176 ml, 2.834 mmol). After chromatographic purification, the product was isolated as a viscous oil (0.480 g, 2.125 mmol). Yield=100%. MS (APCI): 226 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 7.13(bs, 1H), 7.08 (bd, J=7.57 Hz, 1H), 7.05 (d, J=7.57 Hz, 1H), 3.71 (t, J=7.06 Hz, 1H), 3.15 (s, 3H), 3.04 (t, J=7.06 Hz, 2H), 2.20 (s, 3H), 1.75 (s, 3H).

1. customAfter chromatographic purification