Methyl iodide → N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-N-methyl-acetamide

HRID 2211911노트

반응식

HRID 2211911 반응식
[Cl:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[C:6]([CH3:14])[CH:5]=1.I[CH3:16]>>[Cl:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH3:16])[C:11](=[O:13])[CH3:12])=[C:6]([CH3:14])[CH:5]=1

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 21963464N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-acetamide

생성물 1

HCID 21963208N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-N-methyl-acetamide수율 100%

실험 절차

N-[4-(2-Chloro-ethyl)-2-methyl-phenyl]-N-methyl-acetamide was prepared according to the general method as outlined in Preparation 43 starting from N-[4-(2-chloro-ethyl)-2-methyl-phenyl]-acetamide (0.450 g, 2.126 mmol) and iodomethane (0.176 ml, 2.834 mmol). After chromatographic purification, the product was isolated as a viscous oil (0.480 g, 2.125 mmol). Yield=100%. MS (APCI): 226 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 7.13(bs, 1H), 7.08 (bd, J=7.57 Hz, 1H), 7.05 (d, J=7.57 Hz, 1H), 3.71 (t, J=7.06 Hz, 1H), 3.15 (s, 3H), 3.04 (t, J=7.06 Hz, 2H), 2.20 (s, 3H), 1.75 (s, 3H).

후처리

  1. customAfter chromatographic purification

출처 및 근거

ORD 기록
ord-33ece3b554474c1fbe756396eb8561c6
출처 데이터셋
uspto-grants-2006_09
특허 번호
US07101886B2

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